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Researchers have discovered that SGLT2 inhibitors, a class of drugs originally developed to treat diabetes and now widely used for heart failure, work by activating a key enzyme that helps heart cells produce and use energy more efficiently. The study, published today in Science,

Shingles is a painful and serious condition affecting many older people. It is caused by the herpes zoster virus, which can flare up in people who previously had chickenpox. A vaccine against shingles (Zostavax) was introduced in 2006. In many countries, including the U.K. and U.

A private spacecraft failed to rescue NASA's Swift space telescope, meaning the big observatory will come crashing back to Earth in the near future. But details are sparse at the moment.

At least 47 people were killed and more than 50 others kidnapped after armed men attacked a once-peaceful community near Haiti’s capital earlier this week, the United Nations said Tuesday. It is believed to be one of the largest mass kidnappings in Haiti in recent years, and one

Inherited bone marrow failure syndrome, or IBMFS, describes a group of disorders in which inherited genetic abnormalities impair the bone marrow's ability to produce sufficient healthy blood cells. Patients with these disorders are also at increased risk of developing myelodyspla

Problems after power failure at regional signalling centre likely to continue until noon with many crews and trains in wrong locationsBusiness live – latest updatesRail passengers are facing a second day of travel disruption across parts of north-west England, after a power failu

Healthcare staff were unable to properly protect themselves, or those in their care, from dangerous infections, says the latest inquiry report.

Regulator Ofwat confirms this penalty follows three investigations into the water company.

Ofwat investigated supplier over supply interruptions, customer failings and for breaching its licenceSouth East Water will pay £30.5m after a series of supply interruptions, customer failings and for breaching its licence, regulator Ofwat has confirmed.The watchdog said the redress package concludes three investigations into the supplier and includes a previously proposed £22m fine for water supply failures between 2020 and 2023 affecting more than 286,000 people. Continue reading...

Direct oversight of ‘critical third parties’ such as Oracle and Microsoft given to ensure resilient cyber-defences and help safeguard UK economyThe Bank of England has been handed powers to regulate important tech firms including Amazon and Google from next week, amid fears that system failures could threaten financial stability and harm consumers.From Monday, the Bank and fellow City regulator the Financial Conduct Authority (FCA) will be in charge of ensuring that four large-scale pr

Exclusive: Move comes as allies of Andy Burnham work on proposals to take water companies into public controlMinisters are drawing up plans to set legally binding debt targets for England’s water companies as they look for ways to avoid another corporate failure such as Thames Water.Sources say Emma Reynolds, the environment secretary, is working on proposals that would force companies to keep their debt below certain levels for the first time or face legal punishment. Continue reading

Outsourcing firm counts cost of failures that left retired UK civil servants without an income for monthsCapita has revealed that the bill for cleaning up its mess at the crisis-hit Civil Service Pension Scheme could wipe up to £40m off annual profits – a day after its chief executive apologised to MPs for a “very poor service”.The company had faced a grilling at a Commons committee hearing on Wednesday, with its chief executive Adolfo Hernandez repeatedly apologising for failures that